The Woman with the flow of blood healed by touching the hem of Jesus' garment represents the end of the flow of the blood of sheep and goats for the atonement of the sins of Israel!

Mark 5:25-34 KJV

[25] And a certain woman, which had an issue of blood twelve years, [26] and had suffered many things of many physicians, and had spent all that she had, and was nothing bettered, but rather grew worse, [27] when she had heard of Jesus, came in the press behind, and touched his garment. [28] For she said, If I may touch but his clothes, I shall be whole. [29] And straightway the fountain of her blood was dried up; and she felt in her body that she was healed of that plague. [30] And Jesus, immediately knowing in himself that virtue had gone out of him, turned him about in the press, and said, Who touched my clothes? [31] And his disciples said unto him, Thou seest the multitude thronging thee, and sayest thou, Who touched me? [32] And he looked round about to see her that had done this thing. [33] But the woman fearing and trembling, knowing what was done in her, came and fell down before him, and told him all the truth. [34] And he said unto her, Daughter, thy faith hath made thee whole; go in peace, and be whole of thy plague.

https://bible.com/bible/1/mrk.5.25-34.KJV

This woman represents Israel, who for centuries had relied upon the flow of blood from animal sacrifices to atone for  her sins.

Hebrews 9:22 KJV

[22] And almost all things are by the law purged with blood; and without shedding of blood is no remission.

Yet those sacrifices, that constant flow of the blood of animals down through the years could not atone for sin, and was not what God really desired anyway.

However Jesus sacrifice made us holy once and for all.

Hebrews 10:1-10 NIV

[1] The law is only a shadow of the good things that are coming—not the realities themselves. For this reason it can never, by the same sacrifices repeated endlessly year after year, make perfect those who draw near to worship. [2] Otherwise, would they not have stopped being offered? For the worshipers would have been cleansed once for all, and would no longer have felt guilty for their sins. [3] But those sacrifices are an annual reminder of sins. [4] It is impossible for the blood of bulls and goats to take away sins. [5] Therefore, when Christ came into the world, he said: “Sacrifice and offering you did not desire, but a body you prepared for me; [6] with burnt offerings and sin offerings you were not pleased. [7] Then I said, ‘Here I am—it is written about me in the scroll— I have come to do your will, my God.’ ” [8] First he said, “Sacrifices and offerings, burnt offerings and sin offerings you did not desire, nor were you pleased with them”—though they were offered in accordance with the law. [9] Then he said, “Here I am, I have come to do your will.” He sets aside the first to establish the second. [10] And by that will, we have been made holy through the sacrifice of the body of Jesus Christ once for all.

Jesus paid a full, perfect and sufficient sacrifice once and for all, making an end to the constant offering of sin offerings and the flow of the blood of animals to try to attone.

This is symbolised by the woman who had the flow of blood that couldn't be staunched until she came to Christ, but once she came to Christ, the blood ceased to flow!

As for the significance of touching the hem of Jesus' garment, his 'tzitzit', see the below summary courtesy of Google's AI...

The hem of Jesus' garment (specifically the fringes/tzitzit on his prayer shawl) signified divine power, the Word of God, and the fulfillment of prophecy, representing accessibility to God's healing and salvation for those with faith, as seen with the woman with the issue of blood, who believed touching it would bring healing by connecting with His prayer life and the Torah (Numbers 15:38-39). It symbolized His authority and embodiment of God's promises, demonstrating that faith in Him, not just an object, brought deliverance. 

Key Meanings & Significance:

• Connection to the Law & God: The fringes (tzitzit) were commanded by God in the Torah (Numbers 15:38-39) as a reminder of His commandments, linking the garment to God's presence and promises.
• Healing Power: The woman with the issue of blood believed touching the tzitzit would make her whole, recognizing Jesus as the Messiah with God's power in His very being, fulfilling prophecies like Zechariah 8:23.
• Symbol of Scripture: The tassels represented God's Word (Proverbs 4:20-22), and her touch was an act of seeking healing from the "Word made flesh" (John 1:14).
• Authority & Messiahship: It was an acknowledgment that Jesus was the promised one, imbued with divine authority, fulfilling the expectation that people would seek God through Him.
• Accessibility & Faith: Her act showed that healing wasn't about the physical garment but about her deep faith and willingness to break social barriers to reach Jesus, demonstrating His inclusive ministry.
• Fulfillment of Prophecy: Her touch acted as a tangible fulfillment of prophecies foretelling people clinging to the garment of a Jew, recognizing God's presence. 

In essence, touching the hem was a symbolic, faith-filled act to connect with Jesus' divine authority, His life, and the promises of God for healing and salvation, proving that faith in Him is what brings transformation.